Vol. 7, Issue 2, Part B (2025)

This study investigates the effects of quinestrol, a synthetic estrogen, on male reproductive and biochemical parameters in sexually mature male albino rats. A total of 40 rats were divided into two groups: a control group and a treatment group receiving 2 mg/kg of quinestrol for 10 days. Body weight was measured at intervals of 0, 5, and 10 days, revealing no significant differences between groups. However, significant reductions in reproductive organ weights (testis and epididymis) were observed in the quinestrol-treated group. Sperm parameters, including motility, viability, and concentration, were adversely affected, with a notable increase in sperm abnormalities. Biochemically, quinestrol treatment led to significant decreases in total lipid and phospholipid content while cholesterol levels increased in the testis and epididymis. Additionally, total soluble protein content decreased markedly in both reproductive tissues. These findings suggest that quinestrol disrupts the hypothalamic-pituitary-gonadal axis, leading to decreased testosterone synthesis and impaired spermatogenesis, highlighting its potential as a male contraceptive.