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International Journal of Biology Sciences

Vol. 6, Issue 1, Part B (2024)

Assessment of measles virus IgG in children vaccinated with MMR and its correlation with IL-6 and INF-γ in Thi-Qar Province, Iraq

Author(s):

Abdulrahman Seger Gumar and Talib Hassan Ali

Abstract:

Objective: The Measles virus (MeV) is a preventable disease through vaccination, but it has remained an endemic disease in Iraq. 
This study aimed: To evaluate the seroprevalence of IgG antibodies against measles in children who have been vaccinated with the MMR vaccine in the Thi-Qar province, Iraq.
Method: The study design is a case-control study. Included 176 children (117 vaccinated and 59 unvaccinated). The ELISA technique was used to detect the presence of the measles virus IgG in clinical samples collected from children less than 13 years old. IBM SPSS 26 version was used (chi-square, t-test, and ANOVA). The study was conducted in accordance with ethical principles. The committee of researchers at the Thi-Qar Health Directorate (No. 2023/163 on 7/8/2023) has viewed and approved this study. The person's informed consent was obtained.
Results: The seroprevalence of measles virus IgG was positive only in 91 (77.8%) of vaccinated children (case group). while within the unvaccinated (control group), 24 (40.7%) of children were positive. There was a significant difference between both groups (p-value < 0.001). According to sex, there was a significant difference between males and females in the vaccinated group (p-value = 0.028). In contrast to the unvaccinated group, there was no significant difference (p-value = 0.068) by using chi-square. Also, the study showed significant differences between the case and control groups (p-value = 0.002), male and female in the case group (p-value = 0.016), but no significant differences according to the number of doses using the t-test or age group using the ANOVA. The results found a negative correlation with IL-6 (r = -0.191, p-value = 0.039), but no correlation with INF-γ (r = -0.095, p-value = 0.311) by using Pearson correlation. All at a P-value > 0.05.
Conclusion: Iraq is still suffering from the appearance of measles from time to time. According to the findings of this study, which revealed that a portion of children did not develop immunity against the measles virus, their percentage was 22.2%. This may be a negative indicator for measles re-emerging in Iraq. So there must be increased efforts to achieve maximum immunization coverage, educate the population about the importance of vaccination, and perform more studies in many Iraqi cities to ensure measles vaccine efficacy.
 

Pages: 114-119  |  144 Views  66 Downloads

How to cite this article:
Abdulrahman Seger Gumar and Talib Hassan Ali. Assessment of measles virus IgG in children vaccinated with MMR and its correlation with IL-6 and INF-γ in Thi-Qar Province, Iraq. Int. J. Biol. Sci. 2024;6(1):114-119. DOI: 10.33545/26649926.2024.v6.i1b.196
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