Vol. 5, Issue 2, Part B (2023)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic and anti-inflammatory properties but are associated with gastrointestinal side effects, including colitis. N-acetylcysteine (NAC), a known antioxidant and mucolytic agent, has been investigated for its potential protective effects against NSAID-induced colitis. This article explores the therapeutic potential of NAC in mitigating colitis induced by NSAIDs in rat models, highlighting its mechanisms of action, experimental findings, and clinical implications.