Vol. 5, Issue 2, Part A (2023)

The infusion of Strychnos pseudoquina leaves and bark has been used in folk medicine to treat fevers, malaria, liver and stomach conditions, and anemia. Despite its popular use, the mutagenic effects of S. pseudoqunia are unclear. It is important to note that species of this same genus are generally classified as both toxic and mutagenic. The present study evaluated the mutagenic and antimutagenic potential of an aqueous extract of S. pseudoquina bark using the Ames test in Salmonella typhimurium. The concentrations of 0.62, 1.25, 2.5, 5, and 10 mg/plate of S. pseudoquina were evaluated. The results revealed the absence of mutagenicity and antimutagenicity for all tested concentrations of S. pseudoquina, suggesting the potential medicinal value for this plant. Importantly, S. pseudoquina solution can interact with other drugs. We observed that the aqueous extract of S. pseudoquina bark increased the mutagenicity of sodium azide in S. typhimurium by as-yet unknown components and mechanisms. Thus, despite not having mutagenic or antimutagenic actions, the use in association with other drugs may bring unwanted effects. Further scientific data are required to guide clinical practice and safeguard the welfare of users.