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International Journal of Biology Sciences

Vol. 5, Issue 1, Part B (2023)

Demonstration of antidiabetic effect of Asiatic Acid in streptozotocin induced diabetic rat

Author(s):

Nisar Ahmad Ganie and Prashant Agnihotri

Abstract:

Diabetes mellitus is one of most prominent disorder among others spreading at an alarming rate across the globe. The quest to obtain a potential active ingredient for antidiabetic activity is on. The present study was designed to examine the antidiabetic effect of asiatic acid (AA) in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg body weight). Diabetic rats show increased plasma glucose, total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low-density lipoprotein and decreased insulin and high-density lipoprotein in diabetic rats. The antidiabetic effect of AA was compared with glibenclamide, a well-known antihyperglycemic drug. In conclusion, this study indicates that AA showed antidiabetic effect in experimental diabetes.

Pages: 114-122  |  342 Views  100 Downloads


International Journal of Biology Sciences
How to cite this article:
Nisar Ahmad Ganie and Prashant Agnihotri. Demonstration of antidiabetic effect of Asiatic Acid in streptozotocin induced diabetic rat. Int. J. Biol. Sci. 2023;5(1):114-122. DOI: 10.33545/26649926.2023.v5.i1b.156
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